News
12/17/2021: New NIH award!
Excited to announce that NIH-NCI has funded our R21 proposal in collaboration with the Pires Lab: “Chemical Remodeling of Cell Surface to Enhance the Accumulation of Therapeutic Bacteria to Tumors”. Thanks everyone!
7/27/2021: Eden's defense
Congratulations to Dr. Eden (Reichard) Sikorski, who successfully defended her Ph.D. Thesis! She will join Immunome as a Research Scientist.
1/19/2021: New Initiative Grant from Kaufman Foundation
So proud to announce that our collaborative work with Prof. Aurelia Honerkamp-Smith (Physics, Lehigh) has been awarded a New Initiative Grant from the Charles Kaufman Foundation. link
11/15/2020: Two new graduate students!
We welcome two new members to our group: Sophie Rizzo and Samuel Pash.
9/17/2020: Our first R01 Award!
Our proposed studies on promoting the activity of Receptor Protein Tyrosine Phosphatase by targeting their transmembrane interactions has been accepted for funding. See the announcement.
3/20/2020: Article in the Journal of Medicinal Chemistry.
New article in collaboration with the Pires Lab on our effort to selectively tag tumor cells to be recognized by the immune system for destruction. JMC.
11/1/2019: Article on PTPRJ is published in the Journal of Biological Chemistry
Our work on Receptor Protein Tyrosine Phosphatases has been peer-reviewed and is now available at JBC.
6/22/2019: Our first bioRxiv pre-print is out.
Check the hard work of Betty Bloch and Eden Sikorski in collaboration with the Lazzara and Berger groups at UVA: Disrupting the Transmembrane Domain Oligomerization of Protein Tyrosine Phosphatase Receptor J Promotes its Activity in Cancer Cells. bioRxiv
5/19/2019: Hooding of Dr. Janessa Gerhart and Dr. Betty Bloch
Always a great opportunity to wear fancy (and a bit silly) clothing. Congratulations again to Janessa and Betty. photos.
4/18/2019: Congratulations to Dr. Janessa Gerhart!
Dr. Gerhart successfully defended her Ph.D. Thesis on her fabulous work on the development of tumor-selective therapies. The entire group is very proud. She will pursue an academic career as a Teaching Postdoc at Villanova University.
11/15/2018: Welcome to 2 new Graduate Students
We are very happy that Emily Ankrom and Miles Lizak decided to join our group.
6/19/2018: Summer BDSI Grant
Our group, in collaboration with Wonpil Im lab, has been awarded a grant from the Lehigh Biosystems Dynamics Summer Institute to identify new allosteric inhibitors of PTP1B. As part of this initiative, we are happy to welcome Anothony Varshavskiy and Journey Lopez (RARE student) to our group.
9/22/2018: Article published in ACS Chem. Biol.
Janessa Gerhart's work on the development pHLIP-based agents capable of selectively inhibiting the activity of the Epidermal Growth Factor Receptor (EGFR) in cancer cells just got published in ACS Chem. Biol. link
8/15/2018: Congratulations to Eden!
Eden has successfully defended her Ph.D. Thesis Proposal, and is now a Ph.D. candidate!
6/19/2018: Congratulations to Dr. Betty Bloch!
Congratulations to Dr. Bloch, who successfully defended her Ph.D. Thesis on her fantastic studies of the homodimerization of RPTPs. We are all very proud of her. She will pursue her love of teaching as a Science Teacher at the Pomfret Boarding School (Pomfret, CT).
11/10/2017: New article in BBA Biomembranes
This work in collaboration with the Ladokhin Lab article examines the effect of replacing pHLIP's central proline on its pH-triggered lipid-dependent conformational switching: link
01/13/2017: Our latest work just got published
Our work on the selective in vivo delivery and efficacy of pHLIP-MMAF conjugates just got published in Molecular Pharmaceutics: link
6/15/2017: Prof. Anne Reeve joins the group
We are happy to welcome Prof. Anne Reeve (Messiah College, Chemistry) to our group . She is joining the lab as a Senior Research Fellow.
6/17/2017: Congratulations to Dr. Kelly (King) Burns
Congratulations to Dr. (King) Burns, who successfully defended her Ph.D. Thesis. She is the first PhD student to graduate from the Thévenin Lab. We are all very proud of her. She will continue her research endeavor at the US Naval Research Laboratory (Center for Biomolecular Science & Engineering) in Washington, D.C.
11/15/2016: New lab member - Eden Reichard
We are really excited to welcome Eden Reichard in our group. Eden, who has a MS in Chemistry from Villanova University is currently a first year graduate study in the Department of Chemistry. Welcome!
6/2/2016: Check out Kelly's new article published in Scientific Reports
pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates. link
12/1/2015: NIH-NCI Grant on Receptor Protein-Tyrosine Phosphatases
Our lab was awarded an NIH-NCI R21 grant to determine how a receptor protein tyrosine phosphatase physically interacts with itself and with the epidermal growth factor receptor, and how these interactions affect EGFR tyrosine phosphorylation.
9/3/2015: Kelly has published her 2nd article!
Kelly’s second papers has just been accepted for publication in the Biochemical Journal. Congratulations to Kelly! link
8/9/2015: Congratulations to Janessa!
Janessa has successfully defended her Ph.D. Thesis Proposal, and she is now a Ph.D. candidate!
3/5/2015: First Article From the Lab!
The first manuscript form our lab has just been accepted in Molecular Pharmaceutics!! Congratulations to Kelly! link
8/9/2015: Congratulations to Betty!
Betty has successfully defended her Ph.D. Thesis Proposal, and she is now a Ph.D. candidate!
6/17/2014: First NIH-NCI Grant!
Our lab was awarded an NIH-NCI R21 grant to develop and validate the pH(Low) insertion peptide (pHLIP) as a novel therapeutic for prostate cancer.
11/22/2013: New lab member - Janessa Gerhart
We are really excited to welcome Janessa Gerhart in our group. Janessa is currently a first year graduate study in the Department of Chemistry. Welcome!
9/3/2013: Congratulations to Kelly
Kelly has successfully defended her Ph.D. Thesis Proposal, and she is now a Ph.D. candidate!
5/18/2013: Congratulations to Ryan
Congratulations to Ryan McKay for obtaining his M.S. in Bioengineering. Ryan is now officially the first graduate from the Thévenin Lab!! He will be joining the Bioengineering Ph.D. Program at the University of Maryland in the Fall.
1/26/2013: 3 new lab members
The group is very happy to welcome 3 new students: Ryan MacKay, Elizabeth (Betty) Dembicer and Amar Shah. Ryan is a MS student in Bioengineering, Betty is a rising 1st year graduate student in Chemistry and Amar is a sophomore undergraduate student.
5/15/2012: Lehigh University Faculty Innovation Grant
The lab (in collaboration with the Pires group) has received a 2012 Lehigh University FIG for the project: “Selective Delivery of Anti-cancer Agents using Novel Tumor-Targeting Vehicles”.