Welcome to the Thévenin Lab
Membrane biochemistry and targeted drug delivery
The research conducted in our
group lies at the interface of cell biology, chemistry,
biochemistry, and biophysics, with a particular focus on
problems in cancer drug delivery and membrane protein cell
signaling. As such, our work is applied, fundamental, and highly
interdisciplinary. Current research programs are organized
around two main areas:
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Understanding how transmembrane oligomerization control membrane receptors activity and cell signaling.
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Developing novel strategies to specifically target and deliver therapeutics to cancer cells and tumors.
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Identifying and quantifying the biophysical parameters governing flow-mediated transport of membrane proteins.
As such, our work is applied, fundamental, highly interdisciplinary, and draws upon areas such as peptide and protein chemistry, biochemistry, biophysics, molecular, cellular and structural biology, cell signaling, and oncology.
Ongoing projects are aimed at selectively targeting and delivering immunological agents and bacteria to tumors, and at identifying the structural requirements for the dimerization of an understudied, but essential family of membrane receptors, the receptor protein-tyrosine phosphatases (RPTPs).
We are currently funbed by the NIH (R01GM139998, R01GM143320, R21CA259800 and R21CA267087) and the Charles Kaufman Foundation (New Initiative Research Award).
